At the heart of TreeFrog is the desire to rise up to the challenge of industrial production, without compromising quality. Maxime Feyeux’s first and foremost scientific work has been on the topic of pluripotent stem cells genomic integrity.
Our technology enables the delivery of younger cells to mitigate mutational risks. A third party quality control guarantees the genomic integrity of the cell banks we provide.
Vidéo crédit : Gaëlle Recher, CR, LP2N, 3D reconstruction, box sides 100µmX200µmX200µm (In red Oct-4, in green SSEA4 )
For half a decade, Treefrog’s cofounders have been working on making organoids from pluripotent stem cells derived populations. Suddenly organoids are becoming fashionable. This is good news for us and good news for you : ln addition to delivering cell banks, we are capable of massproducing stem-cell derived organoids.
At TreeFrog we believe there is no such thing as barriers between disciplines. Physics and Biology are just beautiful words, and with beautiful words one builds beautiful worlds. Come and join us into the beautiful world of biophysical medicines.
Phase contrast micrograph : Gaëlle Recher, CR, LP2N, scale bar 100µm
Security : Human embryonic stem cells reveal recurrent genomic instability at 20q11.21. Lefort, N., Feyeux, M., Bas, C., Féraud, O., Bennaceur-Griscelli, A., Tachdjian, G., Perrier, A. L. (2008). Nature Biotechnology, 26(12), 1364–1366. https://doi.org/10.1038/nbt.1509
Organoïds : A 3D printed microfluidic device for production of functionalized hydrogel microcapsules for culture and differentiation of human Neuronal Stem Cells (hNSC). Alessandri, K., Feyeux, M., Gurchenkov, B., Delgado, C., Trushko, A., Krause, K.-H., Roux, A. (2016). Lab on a Chip, 16(9), 1593–1604. https://doi.org/10.1039/C6LC00133E
Highthroughput : All-in-one 3D printed microscopy chamber for multidimensional imaging, the UniverSlide. Alessandri, K., Andrique, L., Feyeux, M., Bikfalvi, A., Nassoy, P., & Recher, G.(2017). Scientific Reports, 7(December 2016), 42378. https://doi.org/10.1038/srep42378
Application : Organ size control via hydraulically gated oscillations. Ruiz-Herrero, T., Alessandri, K., Gurchenkov, B. V., Nassoy, P., & Mahadevan, L. (2017). Development, 144(23), 4422–4427. https://doi.org/10.1242/dev.153056
PhD, Pluripotent Stem Cell
Phd, Biophysics Expert
Partner at Bio4ward
Gene & Cell Therapy Industrialization Expert (US,EU), GMP Plateform Installation (US, EU)
MD, PhD Candidate
Imagine institute, Paris
C.R.I. Doctoral School
Experienced in GMP/GLP environment (Fr, CH)
Biotechnology Engineer Student
Co-Founder, PhD, Scientific counsellor,
CNRS Research Director, Biophysicist.
Co-Founder, PhD, Scientific Counsellor, CNRS Research Director
Neurodegenrative Disease Institute Director.
Co-Founder, PhD, Scientific Counsellor,
CNRS Research Director, Physicist.
Intellectual Property Expert, Former Advisor at French Ministry of Research, Former Legal Counsel of Pasteur Institute.
Innovation & International Relationship Special Advisor, Former VP R&D at Sanofi-Aventis, MEDICEN Paris region innovation for health Founding President.
TreeFrog Therapeutics IOA
rue François Mitterrand
33400 Talence – France
TreeFrog Therapeutics is a French stem cell company aiming at supporting the advent and industrial development of stem cell therapies. Our team has developed a unique technology for stem cell culture. Tree Frog Therapeutics provides human induced pluripotent stem cells generation, amplification and banking services for research and therapeutic applications. Our human ipsc banks are provided together with third-party control data about the genomic integrity of the cells. To learn more about our custom stem cell services for research and cell therapy (iPSC generation, iPSC bank amplification, …), please contact us. As a stem cell supplier, we also deliver in vitro stem cell 3D models : stem cell organoids. Such stem cell 3D tissues are more physiologically relevant than stem cell spheroid cultures. Based on MSC or iPSC cells, our organoids are suitable for preclinical proof-of-concept studies, toxicology screening and transplantation studies in the context of regenerative medicine programmes.