The future of cell therapy is here
Powered by our C-Stem™ technology, we produce a unique 3D format microtissue for improved efficacy and safety.
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But first. What is cell therapy ?
We all started as small handful of cells and through division, differentiation and growth, we became a human body with an estimated 37.2 trillion cells with many different cell types carrying out specific functions.
The body’s cells are amazing. Typically, when a cell gets damaged, attacked or simply grows old, they usually die and other cells are created to take their place.
But sometimes, cells do not get replaced, or damaged cells replicate instead of dying.
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Cell Therapy holds immense promise
Cell therapy in its essence, uses the amazing power of cells to replace, repair or regenerate diseased, sick cells and damaged tissues.
In cell therapy, healthy or specially engineered cells are delivered into the body to treat or cure certain types of cancer, genetic disorders and degenerative diseases.
Cell therapy can treat diseases and conditions at a more fundamental level, targeting the root cause at a cellular or tissue level. Cell therapies have the potential to cure a disease, restore function or at the very least, have a much longer-term effect than traditional approaches.
In diseases and conditions where degeneration happens, such as Parkinson’s disease or liver disease, it can promote tissue repair and regeneration.
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Checkout a video from Kévin Alessandri on our approach to cell therapy.
Our lead program
Parkinson's Disease
10 million sufferers worldwide
There is an urgent unmet need for better treatments as only symptomatic relief treatments exist today. A regenerative medicine approach that can replace lost neurons holds immense potential. This is what we are working towards at TreeFrog – a therapy targeting the root causes of the disease, restoring function.
Parkinson’s disease is complex and caused by the progressive loss of neurons in the brain. Diagnosis mostly happens quite late when between 60-80% of dopaminergic neurons are already lost. The disease involves dysfunction at multiple levels in the nervous system with the following symptoms :
Progressive motor symptoms
Bradykinesia, rigidity, resting tremor, postural instability.
Non-motor symptoms
Cognitive deficits, autonomic dysfunctions, and mood disorders, including anxiety and depression.
Our discovery program
Liver Disease
Scientific excellence
A cell therapy with a distinct format for optimal efficacy and safety
Our unique approach uses induced pluripotent stem cells (iPSCs) that are amplified exponentially and then differentiated into dopaminergic neurons in one closed system, using a proprietary platform, C-Stem™.
In contrast with other cell therapy approaches based on the transplantation of single cells, the C-Stem™ generates 3D neural microtissues containing dopaminergic neurons that have several unique benefits in terms of efficacy, safety, and consistency.
Our program is on track for a first-in-human trial by 2026.
- Efficacy
- Safety
- Consistency
Efficacy
It is the only product with the presence of mature neuronswith proven functionality of the network assessed by motor recovery in pre-clinical models.
The 3D format promotes enhanced cell survival post-transplantation and better control over the micro-environment.
Rapid, full recovery in pre-clinical modelspromotes enhanced cell survival post-transplantation and better control over the micro-environment.
Safety
The 3D formatallows for enhanced quality control and batch release is based on actual dopamine quantification.
The 3D graftintegrates well in the brain.
The medical device & delivery methodfacilitates consistent delivery of the product and reliable dose control.
Consistency
The unique C-Stem™ technologydelivers 15 billion cells per batch with 98% viability confirmed through amplification.
The processhas been defined with full reproducibility confirmed and the maintenance of consistent pluripotency across test batches.
The C-Stem™is ready at commercial scale.
The C-Stem™ amplification technology and unique 3D microtissue format hold enormous potential for other diseases
There is a huge unmet need for an off-the-shelf hepatic microtissue that could extend waiting times for liver transplants or ensure hepatic function during liver regeneration for Acute Liver Failure.
We are currently working on a first-in-class iPS-derived cell therapy for this disease based on the following rational:
C-Stem™ can meet the need of over 5 billion cells required per patient which would require >100 billion cells per batch.
3D microtissuesare suitable for the complex tissue architecture of liver needs.
Collaborating
Furthering our expertise with partners
We have several scientific collaborations, co-development & out-licensing agreements. We have tested and validated our technology on 8 cell types including iPSC-derived hepatocytes (liver), natural killer (NK) and cardiac cells, in addition to donor-derived T lymphocytes and NK cells.
