BORDEAUX, France, July 9 th , 2024 – TreeFrog Therapeutics, the French biotech company
advancing a pipeline of regenerative medicine cell therapies based on a disruptive
proprietary technology platform will present at several events at the global stem cell
event in Hamburg, including a poster session with data from their lead program in
Parkinson’s Disease and an innovation showcase with a deep dive on their
transformational technology, C-Stem™.

Regenerative medicine holds immense potential in addressing some of the largest
healthcare unmet needs in diseases of the major organs such as the central nervous
system, the liver, pancreas and heart. However, despite major advances in the last 70
years, there are still bottlenecks holding up innovation, particularly, the ability to produce
the required amount of high-quality cells, efficiently.

TreeFrog’s lead program in Parkinson’s disease has proven efficacy in pre-clinical
models using a unique approach of grafting 3D format microtissues containing
dopaminergic progenitors and mature dopaminergic neurons, as opposed to single-cell
suspensions. The poster, presented by Maxime Feyeux, Chief Scientific Officer and Co-
founder of TreeFrog will highlight the therapeutic potential of the 3D approach, and delve
deeper into the characterization of the product through complementary methods
including qPCR, RNAseq, flow cytometry and microscopy.

The pipeline of TreeFrog is based on their C-Stem™ technology, the culmination of over
20 years of research bringing the best in biophysics and stem cell biology together. This
breakthrough technology addresses the challenges of scale and quality, and the closed
system enables both the amplification and differentiation of cells. Maxime will be joined
by two senior scientists – Joffrey Mianne, Head of iPSC Research and Clement Rieu,
Head of Technologies R&D – during an innovation showcase about C-Stem™.

Presentations details

Poster Presentation: #190 Clinical Applications (CA) Session
Wednesday, July 10, 2024 @ 6:45 PM – 7:45 PM
Room: Poster & Exhibit hall
Innovation Showcase
Thursday July 11 th , 2024 @ 6:00PM – 6:30PM
Room: Hall 3, entrance level

About TreeFrog Therapeutics

TreeFrog Therapeutics is a French-based biotech company set to unlock access to cell
therapies for millions of patients. TreeFrog is unique in its approach to cell therapy development bringing together biophysicists, cell biologists and bioproduction engineers to address the
challenges of the industry — producing and differentiating cells of quality at unprecedented
scale, cost-effectively. To realize their mission of Cell Therapy for all, TreeFrog operates a
business model that includes its own therapeutic programs and partnerships with leading
biotech and industry players in other areas. In the last 3 years, the company has raised $82
million to advance a pipeline of stem cell-based therapies in regenerative medicine. In 2022, the
company opened technological hubs in Boston, USA, and Kobe, Japan, to drive the adoption of
the C-Stem TM platform and establish strategic alliances with leading academic, biotech and
industry players.


Chief Communications Officer
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